It looks like Keito Koume’s manga adaptation of Isuna Hasekura’s Spice & Wolf novels will be coming to an end. According to the January 2018 issue of Dengeki Maoh magazine, the Spice & Wolf manga adaptation will end with its 100th chapter.
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Dengaki Maoh also reveals that their February issue will contain this 100th and final chapter. They will be releasing it in 27th December. As for the tankoubon compilations, the manga entered the final arc back in Volume 13. It will then head towards the finale with Volume 15.
The original Dengeki Bunko light novels follow Karl Kraft and the wise, shape-shifting wolf, Holo. The latter, who seeks to return north, to her original homeland, must keep her identity a secret as they travel, as well as conduct trade with other merchants.